"HEMOLYSIS FOLLOWING TRANSFUSION"

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Prolonged red cell storage before transfusion increases extravascular hemolysis.

BACKGROUND Some countries have limited the maximum allowable storage duration for red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this final week of storage on clinical outcomes. METHODS Sixty healthy adult volunteers were randomized to a single standard, autologous, leukoreduced, packe...

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TRANSFUSION MEDICINE Mouse models of IgG- and IgM-mediated hemolysis

Well-characterized mouse models of alloimmune antibody-mediated hemolysis would provide a valuable approach for gaining greater insight into the pathophysiology of hemolytic transfusion reactions. To this end, mouse red blood cells (mRBCs) from human glycophorin A transgenic (hGPA-Tg) donor mice were transfused into non-Tg recipients that had been passively immunized with IgG or IgM hGPA-specif...

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Hemolysis with rapid transfusion systems in the trauma setting.

OBJECTIVE Rapid infusion system allows rapid infusion of resuscitation fluids at body temperature in trauma patients. Packed red blood cells are subjected to high external pneumatic pressure (up to 300 mm Hg) and rapid infusion rates through a 170-microm filter. This study was conducted to outline hemolysis that may occur in the setting of massive transfusion (> 10 units). METHODS AND MATERIA...

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Chronic Hemolysis Following Mitral Valve Replacement

The incidence and severity of chronic intravascular hemolysis was evaluated in a total of 41 patients following mitral valve replacement. Valve replacement was with a gamma-radiated frame-mounted aortic homograft in 21 patients and with a composite seat Starr-Edwards prosthesis, model 6310 or 6320, in 20 patients. The parameters used to assess hemolysis were hemoglobin, hematocrit, reticulocyte...

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Bronchopleural fistula following intrauterine transfusion.

An infant developed a bronchopleural fistula following intrauterine transfusion given for severe haemolytic disease of the newborn. The fistula was shown to be due to the transfusion being given into the right pleural cavity and lung. Initial treatment along conservative lines is suggested, reserving thoracotomy and lobectomy for use if these simple measures fail. Hypocalcaemia was a complicati...

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ژورنال

عنوان ژورنال: JAMA: The Journal of the American Medical Association

سال: 1922

ISSN: 0098-7484

DOI: 10.1001/jama.1922.02640230060027